LOS ANGELES (AP) — Doctors may be missing "silent strokes" in a small but significant number of children with severe anemia, who may be unfairly labeled as slow learners when in fact they have a medical problem, troubling new research suggests.
Strokes have long been known to be a risk for kids
with sickle cell anemia, an inherited blood disease that affects 70,000 to
100,000 Americans, mostly blacks. The new study finds that strokes are more
common than has been believed in these children.
More surprisingly, the study found that strokes
also were occurring undetected in children who do not have sickle cell but have
other conditions that can cause anemia, such as cancer, kidney failure or blood
loss from trauma such as a car crash.
Some of them have what researchers described as the
brains of 80-year-olds when they were only 5 or 10.
"I don't think there's any reason to
panic," but doctors need to consider the possibility of stroke when
treating any child with severe anemia, said Dr. Michael Dowling, a pediatric
neurologist at the University of Texas Southwestern Medical Center in Dallas.
The study involved only 52 children at one
hospital, but experts in the field believe the findings have wide relevance. At
the study hospital alone, Children's Medical Center Dallas, 1 percent of all
admissions, or about 400 children over 2½ years, were for severe anemia, said
Dowling, who led the research. He presented results Friday at an American
Stroke Association conference.
Out of these 400 children, doctors enrolled 22 with
sickle cell and 30 children with other causes of severe anemia in the study.
These 52 agreed to be tested with a newer type of MRI, or magnetic resonance
imaging scan, that can detect signs of stroke and tell whether it's a recent
one or an older one.
Doctors found fresh strokes were occurring in 4 of
the 22 children with sickle cell, and 2 of the other 30 kids.
Alarmingly, they saw signs of "silent
strokes" in 3 of the 22 sickle cell and 7 of the 30 others. These are
strokes that didn't cause obvious symptoms, such as weakness on one side, but
have still damaged the brain because of too little oxygen due to the severe
anemia.
"We wouldn't have noticed it" without the
MRIs, Dowling said. "Some may be reversible with quick transfusions"
if doctors recognize it while treating the main cause of the anemia, such as
blood loss from an accident.
A federal grant and several foundations sponsored
the study.
Dr. Robert Adams, director of the Medical
University of South Carolina Stroke Center, said the study confirms that stroke
is a major risk in kids with sickle cell and extends it to other children with
severe anemia.
Parents and doctors need to be aware of symptoms of
severe anemia: a child who is pale, tired, possibly with a rapid heartbeat.
"It is something that is very easy to
check," with a simple finger clip device that measures hemoglobin, the
substance in red blood cells that carries oxygen throughout the body, he said.
Copyright
2011 The Associated Press.
